Obesity, high or very high body mass index (BMI between 30 to 35, and BMI>35, respectively), is associated with impairments of sperm quality, especially a decrease in seminal sperm DNA integrity and sperm motility. The negative impact of male obesity on sperm DNA integrity could lead to serious consequences for fertility. Sperm DNA alteration has been linked to an increase time to conception due to impaired fertilization, altered embryo development, lower implantation rates and a higher incidence of miscarriage. Moreover, research also has revealed a recent link between high paternal BMI and decreased live birth outcomes after assisted reproduction treatment. This possibly is due to reduced embryo development, reduced implantation rates and higher pregnancy loss.
Although the underlying reasons are not well known, oxidative stress could be the key mechanism linking overweight or obesity with male infertility by damaging sperm DNA. High BMI and abdominal obesity are correlated to systemic oxidative stress, as assessed in plasma and urine. Men trying to engage in successful fertility should reduce weight to reach a BMI under 30, and take nutritional supplements that protect against oxidative stress. Fruitful for Him includes nutrients for men to increase fertility by protecting testes from oxidative stress and thus creating a better environment for development of healthy sperm.