Infertility is undoubtedly a world-wide problem with 15% of the world’s population suffering from childlessness.
In 2010, an estimated 48.5 million couples worldwide were unable to have a child after five years. It is estimated that 40% of infertility is due to problems in female reproductive system, 40% of infertility cases are due to a male factor’s involvement, and the rest a combination of female and male factors.
In 2010, about 2% of women aged 20–44 years who wanted to have children were unable to have their first live birth (primary infertility), and 10.5% of women with a previous live birth were unable to have an additional live birth (secondary infertility).
This reflects the effect of increased age of both males and females on reduction of fertility.